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Tacodog2470
I'm Italian! I live in the north, which is the "safest" side of the Country - meaning less pickpocketers and scammers, but it really depends on the cities you're going to. Where are you going, if I may ask?
I live in a city that's considered pretty dangerous, but I've never had problems just by following what's considered pretty much common sense here. As others have said above: carry the minimum with you; if you have a backpack make sure it's safe (not easy to open or cut - I personally like better small purses since you can always have an hand of them if you're in a really crowded place); don't stay alone once it's dark (I don't really follow this advice tbh, but better safe than sorry); ignore people that are trying to sell you stuff for charity or such - most of them are scammers.
About the public transports - the service really depends on where you go. I mean, they work and they're the cheapest way to travel around, but the trains usually have at least a 5 minutes delay almost everywhere. We don't have the subway everywhere - cities like Milan and Rome do but the last one is kinda... bad. Be prepared for the smelly, old cabins if you're going there.
Still, this is way cheaper than to rent a car or use a taxi, so if you can't visit everything by feet, go for it! Busses, trains, subways and trams usually have weekly passes that you can get at the vending machines (and they have the English language), take them to spare a few €!
And as the others said about the food,
go for it. Small, family-managed restaurants are usually the best. But be careful about how different our food is to American's one! Like, many, many things that are considered Italian are actually an American version and they are COMPLETELY different here. Pizza is usually very thin and the seasonings have different names or don't exist ("pepperoni pizza" here is "pizza con salame piccante", and "peperoni" in Italian are the sweet peppers); maccheroni and cheese doesn't exist and the maccheroni pasta is another kind of pasta, not those c-shaped ones; pasta bolognese/napoletana doesn't exist; the carbonara is made with pork pillow (not sure if that's how the meat is called in English ahah), almost raw egg and pecorino - a cheese made from goat milk. So really, be careful since many things you might think you know and like might surprise you - in a good or bad way.
For what concerns the people here, we're mostly friendly I'd say. A big, big problem tho is that not everybody speaks English. Instead, few people actually do. If you need help, aim for people that look between 15-30, I'd say that's the most safe range for English speakers ahahah
And yes. We do gesticulate a lot while we speak. Don't be scared it's harmless.
If you have any specific question, please do ask away!