Dogma

An old homeless man (Cort) is standing outside a skee ball arcade in New Jersey and is beaten into a coma by three hockey stick-wielding teenagers, the Stygian Triplets.

Two fallen angels, Bartleby (Affleck) and Loki (Damon), were banished from Heaven after an inebriated Loki, with Bartleby's encouragement, resigned as the Angel of Death. Exiled to Wisconsin, the pair see their salvation when a church in Red Bank, New Jersey celebrates its centennial anniversary with a plenary indulgence. They can have their sins forgiven by passing through the doors of that church, and—upon death—regain access to Heaven. They fail to realize that this will overrule the word of God and destroy existence.

Bethany Sloane (Fiorentino), an abortion clinic worker, attends a sermon in which donations are collected for the hospital bills of the homeless man seen earlier, who was beaten into a coma and is now on life support; with no documentation or living relatives, he is known only as John Doe Jersey. Later that day, Metatron (Rickman), the Voice of God, appears to her and tasks her with preventing Bartleby and Loki's return. Bethany resists the mission, as she lost her faith in God due to her infertility, for which her husband divorced her. Bethany is attacked by the Stygian Triplets, but is saved by Jay and Silent Bob (Mewes and Smith), two prophets whom Metatron said would appear. She is also aided by Rufus (Rock), the thirteenth apostle who was left out of the Bible for being black, and Serendipity (Hayek), a Muse with writer's block.

The demon Azrael (Lee), a former Muse, warns Bartleby and Loki that the forces of Heaven and Hell are attempting to kill them, as Satan will not let them succeed where he has failed. Bethany's party unwittingly meet the angels on a train, where a drunk Bethany reveals her mission to Bartleby. Bartleby threatens to kill Bethany before a melee ensues, in which Silent Bob throws Bartleby and Loki off the train.

Once Bartleby and Loki realize that their plan will destroy all existence, they are divided: Loki wants to back out, while Bartleby is intent on striking back at God for giving humans free will while demanding servitude from angels. Horrified, Loki tells Bartleby that he sounds like Lucifer and refuses to help him any further, but Bartleby strong-arms him into going forward with their plan.

Bethany learns she was chosen for the mission because she is the last relative of Jesus Christ. The group ponders who orchestrated the angels' plan, and Metatron explains that God goes to Earth in human form every now and again to play skee ball, and has gone missing; someone knew enough to incapacitate God but leave Him alive in a mortal form, and thus unable to return to Heaven. The group deduces that Lucifer has as much to lose if Bartleby and Loki succeed as anyone else. Arriving at the church, they fail to persuade Cardinal Glick (Carlin) to cancel the celebration. As revenge, Jay steals Glick's golf club.

When Bartleby and Loki reach the church, Bartleby kills everyone attending the celebration. At a nearby bar, Azrael captures the heroes and explains that he is the mastermind behind the angels' plan; he wants to destroy existence rather than spend eternity in Hell, but he needed to manipulate Bartleby and Loki, as demons cannot become human. Silent Bob kills Azrael with Glick's blessed golf club. Serendipity tells Bethany to bless the sink, making the water in the sink holy; Jay, Rufus and Serendipity kill the Stygian Triplets by dunking their heads into the water.

The heroes reach the church before Bartleby and Loki enter. Loki's wings have been torn off by Bartleby; he is now human and decides to help them. Bartleby kills Loki and fights off Rufus, Serendipity and Bob. During an attempt to seduce Bethany, Jay mentions John Doe Jersey; hoping this is God, Bethany and Bob race to the hospital. Jay shoots off Bartleby's wings with a submachine gun, turning him human.

Bethany removes John Doe Jersey's life support, allowing God to escape while inadvertently killing herself. In the form of a woman, God (Morissette) manifests at the church before a remorseful Bartleby, and kills him with the power of Her voice. Silent Bob shows up with Bethany's corpse. God resurrects Bethany and conceives a child inside her. God, Rufus, Metatron, and Serendipity return to Heaven, leaving Bethany, Jay and Bob to reflect on what has happened.